Croscarmellose Sodium Cel-Ca-Dissol®
Cellulose Acting as a Catalyst for Dissolution
Modified Sodium Carboxy Methyl Cellulose
Crosslinked Sodium Carboxy Methyl Cellulose
As importance of bio-availability and fast disintegration of pharmaceutical tablet is realised, awarness for super-disintegrants in pharmaceutical tablet formulation is also increasing . Superdisintegrant viz. Sodium Starch Glycollate was also introduced by Maple Biotech Pvt Ltd. in year 1991, which was appreciated in quality and performance by pharmaceutical industry . Although quest for superior quality superdisintegrant was not over . Superdisintegrant with better stability and superior performance at high tablet hardness level was sought and Maple Biotech's R & D department developed the product Crosslinked Sodium Carboxy Methyl Cellulose which is bearing brand name Cel-Ca-Dissol.
PROPERTIES
Cel-Ca-Dissol is white or creamish white in colour and chemically it is cross-linked Sodium Carboxy Methyl Cellulose with very high degree of purity . Very hard tablets where other superdisintegrants do not perform well Cel-Ca-Dissol performs very much satisfactorily. Quantity to be used in pharmaceutical formulation is very less. Cel-Ca-Dissol is required almost half the amount of other brands of Crosslinked Sodium Carboxy Methyl Cellulose to acheive similiar performance of tablet dissolution
ADVANTAGES
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good water uptake
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high capillary action
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rapid swelling properties
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efficient fluid channeling compatibility with most actives and excipients
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excellent long-term stability
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low usage level
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low cost-in-use
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very fast drug dissolution